MiRNA expression profiles in SPE and normal placentas were investigated using an Ion Torrent sequencing system. The present study analyzed the placental miRNA expression profile in pregnancies complicated by SPE. Whether and how the miRNA expression pattern is changed in the SPE placenta remains unclear. PE is associated with an altered microRNA (miRNA) expression pattern in the placenta, suggesting that miRNA deregulation is involved in the pathogenesis of PE. Preexisting hypertension in women developing PE, also known as superimposed PE on chronic hypertension (SPE), leads to elevated risk of maternal and fetal mortality. It is usually diagnosed based on the de novo onset of hypertension and proteinuria. Pre-eclampsia (PE) is a complication of pregnancy that affects 5‑8% of women after 20 weeks of gestation.
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Report of the National high blood pressure. Library preparation and Ion Torrent sequencing were supported by the Russian Scientific. Statistical analysis was performed using Statistica 10.0 (StatSoft.
